@article{Nagendrababu2024586,

title = {Knowledge of undergraduate and postgraduate dental students about managing traumatic dental injuries based on the 2020 International Association of Dental Traumatology guidelines: A online survey of 10 dental schools from 10 countries},

author = {Venkateshbabu Nagendrababu and Vellore Kannan Gopinath and Ana Arias and Frank C. Setzer and Meric Karapinar Kazandag and Anil Kishen and Francesco Mannocci and Raghavendra M. Shetty and Srinivasan Narasimhan and Wataru Ode and Sushmita Ravindran and Nandini Suresh and Igor Tsesis and Victoria Yu and Paul V. Abbott},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85192066696&doi=10.1111%2fedt.12961&partnerID=40&md5=d8aaab152015e9b1e7e9dcdc6a21decb},

doi = {10.1111/edt.12961},

issn = {16004469},

year  = {2024},

date = {2024-01-01},

journal = {Dental Traumatology},

volume = {40},

number = {5},

pages = {586 – 598},

publisher = {John Wiley and Sons Inc},

abstract = {Background/Aim: The knowledge of dental students about managing traumatic dental injuries (TDIs) may not be uniform, depending on global location and dental education. The aim of this study was to evaluate the level of knowledge of undergraduate and postgraduate students specializing in endodontics and pediatric dentistry at 10 dental schools in 10 countries about the 2020 International Association of Dental Traumatology (IADT) guidelines regarding the management of TDIs. Materials & Methods: A previously published questionnaire was used in the current survey. It was an online survey with 12 questions regarding the management of TDIs and some additional questions regarding sociodemographic and professional profiles of the participants were added. The survey was distributed to final-year undergraduate students and postgraduate students in pediatric dentistry and endodontics from 10 dental schools. Simple frequency distributions and descriptive statistics were predominantly used to describe the data. Differences in the median percentage scores among the student categories were assessed using the Kruskal–Wallis test followed by Dwass–Steel–Critchlow–Fligner pairwise comparisons. Results: A total of 347 undergraduates, 126 postgraduates in endodontics, and 72 postgraduates in pediatric dentistry from 10 dental schools participated in this survey. The postgraduates had a significantly higher percentage score for correct responses compared with the undergraduates. No significant difference was observed between the endodontic and pediatric dentistry postgraduates. Conclusion: The knowledge possessed by undergraduate and postgraduate students concerning the IADT-recommended management of TDIs varied across the globe and some aspects were found to be deficient. This study emphasizes the critical importance of reassessing the teaching and learning activities pertaining to the management of TDIs. © 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.},

note = {Cited by: 8},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae20241539,

title = {Insights Into the November 2024 Issue of the Journal of Endodontics},

author = {Anita Aminoshariae and Amir Azarpazhooh and Ashraf F. Fouad and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85208275768&doi=10.1016%2fj.joen.2024.10.007&partnerID=40&md5=1281dad803c4a8365a4c6c559000bcfc},

doi = {10.1016/j.joen.2024.10.007},

issn = {00992399},

year  = {2024},

date = {2024-01-01},

journal = {Journal of Endodontics},

volume = {50},

number = {11},

pages = {1539 – 1541},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Boveda2024637,

title = {Pericervical Dentin Metrics in Mandibular First Molars Determined with Digital Periapical Radiography and Cone-beam Computed Tomography},

author = {Carlos Boveda and Anil Kishen and Beatriz Millan and María V. Camejo and Jose Francisco Gomez-Sosa},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85187008761&doi=10.1016%2fj.joen.2024.02.003&partnerID=40&md5=c9cae204b5dbf30ed26bec69bcb06848},

doi = {10.1016/j.joen.2024.02.003},

issn = {00992399},

year  = {2024},

date = {2024-01-01},

journal = {Journal of Endodontics},

volume = {50},

number = {5},

pages = {637 – 643},

publisher = {Elsevier Inc.},

abstract = {Introduction: Pericervical root dentin is decisive for the long-term mechanical integrity of root-filled teeth. Current treatment protocol does not include a customized step to determine the pretreatment residual pericervical root dentin. Objective: To determine and compare the residual root dentin and canal width using digital periapical radiography (DPR) and cone-beam computed tomography (CBCT) at the apical limit of the pericervical area (PCA) in mandibular first molars. Methods: DPR and CBCT images of 60 patients with age between 22 and 76 years were used to determine (a) the mesiodistal widths of the root canal (pericervical dimensions [PCL]-C) and the root (PCL-R) of mandibular first molars at the apical limit of the PCA and (b) the intracanal distance from the apical limit of the PCA to the radiographic apex (intracanal distance [ICD]). The correlation between the PCL and ICD measurements obtained from DPR and CBCT were evaluated. Results: Values between 0.10–0.80 mm and 0.00–1.10 mm were obtained for PCL-C using DPR and CBCT respectively (95% CI). The PCL values between 0.90–2.30 mm and 0.00–2.30 mm were obtained from DPR and CBCT respectively (95% CI). The ICD ranged between 4.6–12.3 mm in DPR and 4.40–12.0 mm in CBCT (95% CI). The comparative analysis showed differences from −0.9 to 0.5 mms for PCL and −2.00 to 1.5 mms for ICD between DPR and CBCT techniques respectively. Conclusion: The PCL and ICD determined from DPR and CBCT provided the pericervical dentin metrics that could be utilized clinically as a guideline for decision-making in endodontic treatment. © 2024 American Association of Endodontists},

note = {Cited by: 1},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae20231585,

title = {Insights into the December 2023 Issue of the Journal of Endodontics},

author = {Anita Aminoshariae and Amir Azarpazhooh and Ashraf F. Fouad and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85176127339&doi=10.1016%2fj.joen.2023.11.001&partnerID=40&md5=f29458f84cc184bd8e66147424299d78},

doi = {10.1016/j.joen.2023.11.001},

issn = {00992399},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Endodontics},

volume = {49},

number = {12},

pages = {1585 – 1587},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Teed2023198,

title = {Synchronized Microbubble Photodynamic Activation to Disinfect Minimally Prepared Root Canals},

author = {Christine Teed and Hebatullah Hussein and Anil Kishen},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146684245&doi=10.1016%2fj.joen.2022.12.003&partnerID=40&md5=30d55984aefb704a496eb9baa0121bd8},

doi = {10.1016/j.joen.2022.12.003},

issn = {00992399},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Endodontics},

volume = {49},

number = {2},

pages = {198 – 204},

publisher = {Elsevier Inc.},

abstract = {Introduction: The purpose of this study was to evaluate the antimicrobial efficacy of a novel irrigation strategy using synchronized microbubble photodynamic activation (SYMPA) in a minimally prepared single canal. Methods: Single-canal mandibular incisors were inoculated with Enterococcus faecalis for 3 weeks and randomly allocated to 4 groups based on the irrigation protocols: (1) control (saline), (2) conventional needle irrigation (CI), (3) ultrasonic-assisted irrigation (UI), and (4) irrigation with SYMPA. The first 3 groups were instrumented to size 25.07v (WaveOne Gold Primary; Dentsply Sirona, Johnson City, TN), and the SYMPA group was minimally prepared to size 20.07v (WaveOne Gold Small, Dentsply Sirona). The apical 5 mm was resected for microbiological assessment using the culture technique (colony-forming unit), adenosine-5′-triphosphate–based viability assay (relative luminescence units), and the percentage of live bacteria using confocal laser scanning microscopy. Results: Log colony-forming units from the UI (2.37 ± 0.66) and SYMPA (2.21 ± 0.86) groups showed a reduction compared with the control (5.16 ± 0.75) and CI (4.08 ± 1.19) groups. Relative luminescence unit reduction was significant for UI (619.08 ± 352.78) and SYMPA (415.25 ± 329.51) compared with the control (1213.2 ± 880.03) (P < .05). The percentage of live bacteria was significantly lower in the UI and SYMPA groups compared with the control and CI groups. Although higher microbial reduction was observed in SYMPA compared with UI, there was no statistical significance (P > .05). Conclusion: SYMPA in minimally prepared canals showed significant antimicrobial efficacy. The novel irrigation strategy using SYMPA could be an effective disinfection strategy for minimally prepared root canals. © 2022 American Association of Endodontists},

note = {Cited by: 12},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Gurucharan2023486,

title = {Characterization of nano-hydroxyapatite incorporated carboxymethyl chitosan composite on human dental pulp stem cells},

author = {Ishwarya Gurucharan and Balasubramanian Saravana Karthikeyan and Sekar Mahalaxmi and Kaviya Baskar and Gurusamy Rajkumar and Vijayakumar Dhivya and Anil Kishen and Seshadri Sankaranarayanan and Natanasikamani Gurucharan},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146282521&doi=10.1111%2fiej.13885&partnerID=40&md5=69022628821e8317be6febceb0f7246a},

doi = {10.1111/iej.13885},

issn = {01432885},

year  = {2023},

date = {2023-01-01},

journal = {International Endodontic Journal},

volume = {56},

number = {4},

pages = {486 – 501},

publisher = {John Wiley and Sons Inc},

abstract = {Aim: To compare the odontogenic differentiation potential of a composite scaffold (CSHA) comprising of nano-hydroxyapatite (nHAp) and carboxymethyl chitosan (CMC) with Biodentine on human dental pulp stem cells (hDPSCs). Methodology: A CSHA scaffold was prepared through an ultrasonication route by adding nHAp and CMC (1:5 w/w) in water medium followed by freeze-drying. Physicochemical characterization was achieved using scanning electron microscopy with energy-dispersive X-ray spectroscopy, X-ray diffraction and Fourier transform infrared spectroscopy. In-vitro bioactivity and pH assessments were done by soaking in simulated body fluid (SBF) for 28 days. The angiogenic and odontogenic differentiation abilities were assessed by expression of vascular endothelial growth factor (VEGF) and Dentine sialophosphoprotein (DSPP) markers on cultured hDPSCs by flow cytometry and RT-qPCR at 7, 14 and 21 days. Cell viability/proliferation and biomineralization abilities of CSHA were compared with Biodentine by MTT assay, alkaline phosphatase (ALP) activity, Alizarin Red Staining (ARS) and osteopontin (OPN) expression on hDPSCs following 7 and 14 days. Data were statistically analysed with Kruskal Wallis and Friedman tests as well as one way anova followed by appropriate post hoc tests (p <.05). Results: Characterization experiments revealed a porous microstructure of CSHA with pore diameter ranging between 60 and 200 μm and 1.67 Ca/P molar ratio along with the characteristic functional groups of both HAp and CMC. CSHA displayed bioactivity in SBF by forming apatite-like crystals and maintained a consistent pH value of 7.70 during 28 days' in vitro studies. CSHA significantly upregulated VEGF and DSPP levels on hDPSCs on day 21 compared with day 7 (p <.05). Further, CSHA supported cell viability/proliferation over 14 days like Biodentine with no statistical differences (p >.05). However, CSHA exhibited increased ALP and ARS activity with an intense OPN staining compared with Biodentine after 14 days (p <.05). Conclusion: The results highlighted the odontogenic differentiation and biomineralization abilities of CSHA on hDPSCs with significant VEGF and DSPP gene upregulations. Further, CSHA exhibited enhanced mineralization activity than Biodentine, as evidenced by increased ALP, ARS and OPN activity on day 14. The nHAp-CMC scaffold has the potential to act as an effective pulp capping agent; however, this needs to be further validated through in-vivo animal studies. © 2022 British Endodontic Society. Published by John Wiley & Sons Ltd.},

note = {Cited by: 19},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ghaffari2023,

title = {Endocytic internalization mechanism of bioactive antibacterial nanoparticles by fibroblasts},

author = {Maryam Ghaffari and Anil Kishen and Annie Shrestha},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85153612705&doi=10.1016%2fj.jpap.2023.100179&partnerID=40&md5=c6e86b6349fb2de65da43df74c706f14},

doi = {10.1016/j.jpap.2023.100179},

issn = {26664690},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Photochemistry and Photobiology},

volume = {15},

publisher = {Elsevier B.V.},

abstract = {Studying the uptake mechanism of photosensitizers is an important step in developing an ideal photosensitizer for use in photodynamic therapy (PDT). Understanding the uptake mechanism can help design novel photosensitizers that are selectively accumulated in the target tissue, with improved pharmacokinetics, and are dosed optimally to maximize the efficacy of the treatment. In our previous studies we synthesized and characterized the use of chitosan nanoparticles functionalized with rose bengal (CSRBnp) as a photosensitizer against dental biofilm. The aim of this study is to analyze the internalization mechanism and cellular proinflammatory activities of CSRBnps on fibroblasts. Fibroblasts (NIH 3T3) were incubated with chlorpromazine (5 µg/ml), nystatin (5 µg/ml), wortmannin (100 ng/ml) and at 4 °C for 30 min followed by CSRBnp (0.3 mg/ml). Cell viability (MTS assay), intracellular adenosine triphosphate content (Luminescence assay), cytokine expression (TNF-α) using ELISA and nitric oxide (NO) production by Griess reaction system were conducted at different time intervals (30 min, 1, 4, and 12 h). The internalization of CSRBnps was analyzed using live cell imaging confocal microscope with excitation wavelengths of 405 and 568 to detect nuclei (Hoechst 33,342) and CSRBnps respectively. CSRBnps and inhibitors at the applied concentrations were not cytotoxic. ATP content in chlorpromazine and without inhibitors groups were significantly lower than the control group at 12 h. All inhibitors showed significantly lower CSRBnps uptake compared to the control group at 30 min, 1 h, and 4 h time. Wortmannin resulted in the most significant inhibition of CSRBnps uptake as compared to chlorpromazine and nystatin (P < 0.05). TNF-α expression and NO production were not significant during the entire CSRBnps uptake. The results showed macropinocytosis was a dominant CSRBnps uptake mechanism by fibroblasts in the early stages and non-specific uptake pathways were activated after prolonged incubation time. CSRBnps uptake by fibroblasts was energy dependent and did not cause any proinflammatory response. © 2023},

note = {Cited by: 0; All Open Access, Gold Open Access},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bafail2023162,

title = {Effect of Odanacatib on the release of NTX (Amino Terminal Telopeptide) from LPS contaminated type I dentin collagen},

author = {Arwa Bafail and Karina Midori Mori Carneiro and Anil Kishen and Anuradha Prakki},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85147330885&doi=10.1016%2fj.dental.2022.12.004&partnerID=40&md5=2cb027a646359c4907fd5ba389454d48},

doi = {10.1016/j.dental.2022.12.004},

issn = {01095641},

year  = {2023},

date = {2023-01-01},

journal = {Dental Materials},

volume = {39},

number = {2},

pages = {162 – 169},

publisher = {Elsevier Inc.},

abstract = {Objective: To evaluated the Odanacatib inhibitor treatment on lipopolysaccharide (LPS) contamination effect on cathepsin-K mediated dentin degradation by analysis of type I collagen C- and N-termini telopeptides. Methods: Pulverized and disks of human dentin were demineralized and LPS contaminated, or stored in deionized water (DW) for 12 h. Samples were challenged with lactic acid (LA). Aliquots of dentin powder were treated with 1 mL Odanacatib or stored in DW for 30 min. Dentin collagen degradation was determined by sub-product release of C-terminal (ICTP and CTX) and N-terminal (NTX) telopeptides, normalized to total protein (tp) concentration (n = 3). Dentin matrix was evaluated for gravimetric (n = 8) and ultrastructural changes. Data were analyzed by Student t-test, one-way ANOVA and Tukey's test (α = 5 %). Results: LA incubation significantly increased telopeptide release compared with DW (p < 0.05). In untreated groups, significantly higher CTXtp, NTXtp telopeptide rates were observed for LA+LPS samples compared with DW (p < 0.01). Odanacatib significantly reduced ICTPtp, CTXtp, and NTXtp telopeptide release for LPS, LA, and LA+LPS conditions. In untreated groups, LPS and LA+LPS challenge significantly increased dentin weight loss (p = 0.02). Within each storage condition, Odanacatib treatment did not affect weight change (p > 0.05) of dentin disks. Significance: This study showed that LPS contamination resulted in significantly higher rates of NTX than CTX from dentin matrix. Odanacatib significantly reduced telopeptide release rates of LPS contaminated dentin matrix. © 2022 The Academy of Dental Materials},

note = {Cited by: 2},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae2023619,

title = {Insights into the June 2023 Issue of the Journal of Endodontics},

author = {Anita Aminoshariae and Amir Azarpazhooh and Ashraf F. Fouad and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85163092300&doi=10.1016%2fj.joen.2023.05.001&partnerID=40&md5=02008bba0f13a67091aa2be69a93e92c},

doi = {10.1016/j.joen.2023.05.001},

issn = {00992399},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Endodontics},

volume = {49},

number = {6},

pages = {619 – 621},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae2023107,

title = {Insights into the February 2023 Issue of the JOE},

author = {Anita Aminoshariae and Amir Azarpazhooh and Ashraf F. Fouad and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146036879&doi=10.1016%2fj.joen.2022.12.012&partnerID=40&md5=bff1b07235d2e51a05c9632c67657b3a},

doi = {10.1016/j.joen.2022.12.012},

issn = {00992399},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Endodontics},

volume = {49},

number = {2},

pages = {107 – 109},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae2023237,

title = {Insights into the March 2023 Issue of the JOE},

author = {Anita Aminoshariae and Amir Azarpazhooh and Ashraf F. Fouad and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85148967628&doi=10.1016%2fj.joen.2023.02.006&partnerID=40&md5=70d25aec73938f60f5b16bd64ce4d58e},

doi = {10.1016/j.joen.2023.02.006},

issn = {00992399},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Endodontics},

volume = {49},

number = {3},

pages = {237 – 239},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bakhtiar2023718,

title = {Fabrication and characterization of a novel injectable human amniotic membrane hydrogel for dentin-pulp complex regeneration},

author = {Hengameh Bakhtiar and Mohammad Reza Mousavi and Sarah Rajabi and Mohammad Pezeshki-Modaress and Alireza Ayati and Azin Ashoori and Mohammad Reza Ellini and Khadijeh Baaji and Amir Kamali and Zhila Abediasl and Amir Azarpazhooh and Anil Kishen},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85163536318&doi=10.1016%2fj.dental.2023.06.008&partnerID=40&md5=7fba8348fd2a965e82d5ff06a8ddeaa8},

doi = {10.1016/j.dental.2023.06.008},

issn = {01095641},

year  = {2023},

date = {2023-01-01},

journal = {Dental Materials},

volume = {39},

number = {8},

pages = {718 – 728},

publisher = {Elsevier Inc.},

abstract = {Objective: Injectable biomaterials that can completely fill the root canals and provide an appropriate environment will have potential application for pulp regeneration in endodontics. This study aimed to fabricate and characterize a novel injectable human amniotic membrane (HAM) hydrogel scaffold crosslinked with genipin, enabling the proliferation of Dental Pulp Stem Cells (DPSCs) and optimizing pulp regeneration. Methods: HAM extracellular matrix (ECM) hydrogels (15, 22.5, and 30 mg/ml) crosslinked with different genipin concentrations (0, 0.1, 0.5, 1, 5, and 10 mM) were evaluated for mechanical properties, tooth discoloration, cell viability, and proliferation of DPSCs. The hydrogels were subcutaneously injected in rats to assess their immunogenicity. The hydrogels were applied in a root canal model and subcutaneously implanted in rats to determine their regenerative potential for eight weeks, and histological and immunostaining analyses were performed. Results: Hydrogels crosslinked with low genipin concentration demonstrated low tooth discoloration, but 0.1 mM genipin crosslinked hydrogels were excluded due to their unfavourable mechanical properties. The degradation ratio was lower in hydrogels crosslinked with 0.5 mM genipin. The 30 mg/ml-0.5 mM crosslinked hydrogel exhibited a microporous structure, and the modulus of elasticity was 1200 PA. In vitro, cell culture showed maximum viability and proliferation in 30 mg/ml-0.5 mM crosslinked hydrogel. All groups elicited minimum immunological responses, and highly vascularized pulp-like tissue was formed in human tooth roots in both groups with/without DPSCs. Significance: Genipin crosslinking improved the biodegradability of injectable HAM hydrogels and conferred higher biocompatibility. Hydrogels encapsulated with DPSCs can support stem cell viability and proliferation. In addition, highly vascularized pulp-like tissue formation by this biomaterial displayed potential for pulp regeneration. © 2023 The Academy of Dental Materials},

note = {Cited by: 12},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Jafarzadeh2023496,

title = {Bone Regeneration Effect of Nanochitosan with or without Temporally Controlled Release of Dexamethasone},

author = {Hamid Jafarzadeh and Siavash Moushekhian and Narges Ghazi and Majdoddin Vahidi and Ali Bagherpour and Reyhaneh Shafieian and Shahin Moeini and Ali Kazemian and Amir Azarpazhooh and Anil Kishen},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151396225&doi=10.1016%2fj.joen.2023.03.001&partnerID=40&md5=0b27d8945f73076b787087245406ed7d},

doi = {10.1016/j.joen.2023.03.001},

issn = {00992399},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Endodontics},

volume = {49},

number = {5},

pages = {496 – 503},

publisher = {Elsevier Inc.},

abstract = {Introduction: Chitosan is a cationic biopolymer, and its modification as a nanoparticle as well as loading a corticosteroid on it may enhance its bone regenerative effect. The aim of this study was to investigate the bone regenerative effect of nanochitosan with or without dexamethasone. Methods: Under general anesthesia, 4 cavities were created in the calvarium of 18 rabbits and filled with nanochitosan, nanochitosan with a temporally controlled release of dexamethasone (nanochitosan + dexamethasone), an autograft, or left unfilled (control). The defects were then covered with a collagen membrane. The rabbits were randomly divided into 2 groups and were sacrificed at 6 or 12 weeks after surgery. The new bone type, osteogenesis pattern, foreign body reaction, and the type and severity of the inflammatory response were evaluated histologically. The amount of new bone was determined using histomorphometry and cone-beam computed tomographic imaging. One-way analysis of variance with repeated measures was performed to compare results between the groups at each interval. A t test and chi-square test were also conducted to analyze changes in variables between the 2 intervals. Results: Nanochitosan and the combination of nanochitosan and dexamethasone significantly increased the combination of woven and lamellar bone (P = .007). No sample showed a foreign body reaction or any acute or severe inflammation. Chronic inflammation was significantly decreased in number (P = .002) and severity (P = .003) over time. There was no significant difference between the extent and pattern of osteogenesis among the 4 groups, as evaluated by histomorphometry and cone-beam computed tomographic imaging at each interval. Conclusion: Nanochitosan and nanochitosan + dexamethasone were comparable with the gold standard of autograft regarding the type and severity of inflammation as well as the level and pattern of osteogenesis; yet, they induced more woven and lamellar bone. © 2023 American Association of Endodontists},

note = {Cited by: 5},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae2023773,

title = {Insights into the July 2023 Issue of the Journal of Endodontics},

author = {Anita Aminoshariae and Amir Azarpazhooh and Ashraf F. Fouad and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85162163682&doi=10.1016%2fj.joen.2023.06.001&partnerID=40&md5=0c288e14dd565eb7b2bd77a0165786ea},

doi = {10.1016/j.joen.2023.06.001},

issn = {00992399},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Endodontics},

volume = {49},

number = {7},

pages = {773 – 775},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae20231087,

title = {Insights Into the September 2023 Issue of the JOE},

author = {Anita Aminoshariae and Amir Azarpazhooh and Ashraf F. Fouad and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85168491805&doi=10.1016%2fj.joen.2023.08.001&partnerID=40&md5=ff3b6a2740478c815afe18ada3fb459e},

doi = {10.1016/j.joen.2023.08.001},

issn = {00992399},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Endodontics},

volume = {49},

number = {9},

pages = {1087 – 1089},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae20231227,

title = {Insights into the October 2023 Issue of the Journal of Endodontics},

author = {Anita Aminoshariae and Amir Azarpazhooh and Ashraf F. Fouad and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85171792825&doi=10.1016%2fj.joen.2023.08.022&partnerID=40&md5=ff61093a7345620a8b797f8d41b57d46},

doi = {10.1016/j.joen.2023.08.022},

issn = {00992399},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Endodontics},

volume = {49},

number = {10},

pages = {1227 – 1229},

publisher = {Elsevier Inc.},

note = {Cited by: 1},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Moriya20231399,

title = {Quasi-3D dynamic photoelastic analysis of stress distribution during preparation of simulated canals with 13 mechanical preparation systems},

author = {Paulo Takeji Moriya and Kleber Kildare Teodoro Carvalho and Anil Kishen and Erick M. Souza and Marco A. Versiani},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85167680787&doi=10.1111%2fiej.13961&partnerID=40&md5=7359c20416b50f14209353a316734a66},

doi = {10.1111/iej.13961},

issn = {01432885},

year  = {2023},

date = {2023-01-01},

journal = {International Endodontic Journal},

volume = {56},

number = {11},

pages = {1399 – 1411},

publisher = {John Wiley and Sons Inc},

abstract = {Aim: The aim of this study is to compare the stress produced on the internal walls of simulated canals by nine rotary and four reciprocating systems. Methodology: Sixty-five isotropic transparent blocks containing a 60° curved and tapered simulated canal were selected and distributed into 13 groups (n = 5) according to the preparation system: BioRace, HyFlex EDM, iRaCe, Mtwo, One RECI, ProTaper Next, RaCe EVO, Reciproc, Reciproc Blue, R-Motion, VDW.ROTATE, XP-Endo Rise Shaper, and XP-Endo Shaper. Each resin block was mounted in a vice and a digital camera recorded the entire sequence of each preparation system through a circular polariscope set for dark field analysis. The video frames when each instrument reached the end of the coronal, middle, and apical thirds of the canal were extracted from the recordings and analysed by two independent observers regarding the stress generated on the canal walls using a semi-quantitative evaluation on a 0–5 scale. Intra- and inter-observer agreement were subjected to the Cohen's Kappa coefficient test, whilst the experimental results were compared using Kruskal‑Wallis test post hoc pairwise comparisons with Bonferroni correction (α = 5%). Results: The inter- and intra-observer agreement were 0.98 and 1, respectively. Most instruments demonstrated acceptable performance (scores ≤ 2) in all thirds. Other instruments, such as the HyFlex EDM 25.12 (coronal and middle thirds), Reciproc Blue R25 and Reciproc R25 (coronal and apical thirds), R-Motion 30.04 (apical third), and VDW.ROTATE 20.05 (apical third) showed scores higher than 3. Statistical analysis revealed a significant difference amongst the tested systems at the coronal, middle, and apical thirds (p <.05). Conclusion: None of the canal instrumentation protocols were stress-free, showing varying levels of stress concentrations. Various factors seemed to influence the magnitude of stress and its distribution pattern on the canal walls. Overall, instruments characterized by a larger taper, lower speed, reciprocating motion, and made of heat-treated NiTi alloy exhibited higher patterns of stress distribution. © 2023 British Endodontic Society. Published by John Wiley & Sons Ltd.},

note = {Cited by: 9},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Afkhami2023,

title = {Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review},

author = {Farzaneh Afkhami and Parisa Forghan and James L. Gutmann and Anil Kishen},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151426185&doi=10.3390%2fpharmaceutics15030715&partnerID=40&md5=f991c280b91fd9ed85b8e00ca0cd8ef4},

doi = {10.3390/pharmaceutics15030715},

issn = {19994923},

year  = {2023},

date = {2023-01-01},

journal = {Pharmaceutics},

volume = {15},

number = {3},

publisher = {MDPI},

abstract = {The efficient elimination of microorganisms and their byproducts from infected root canals is compromised by the limitations in conventional root canal disinfection strategies and antimicrobials. Silver nanoparticles (AgNPs) are advantageous for root canal disinfection, mainly due to their wide-spectrum anti-microbial activity. Compared to other commonly used nanoparticulate antibacterials, AgNPs have acceptable antibacterial properties and relatively low cytotoxicity. Owing to their nano-scale, AgNPs penetrate deeper into the complexities of the root canal systems and dentinal tubules, as well as enhancing the antibacterial properties of endodontic irrigants and sealers. AgNPs gradually increase the dentin hardness in endodontically treated teeth and promote antibacterial properties when used as a carrier for intracanal medication. The unique properties of AgNPs make them an ideal additive for different endodontic biomaterials. However, the possible side effects of AgNPs, such as cytotoxicity and tooth discoloration potential, merits further research. © 2023 by the authors.},

note = {Cited by: 34; All Open Access, Gold Open Access, Green Open Access},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae2023351,

title = {Insights into the April 2023 Issue of the Journal of Endodontics},

author = {Anita Aminoshariae and Amir Azarpazhooh and Ashraf F. Fouad and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85150862754&doi=10.1016%2fj.joen.2023.03.002&partnerID=40&md5=b4111e23ab1f2ff7f4657ba37ba6e3d8},

doi = {10.1016/j.joen.2023.03.002},

issn = {00992399},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Endodontics},

volume = {49},

number = {4},

pages = {351 – 353},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rajeshwari20231145,

title = {Periodontal Fibroblasts—Macrophage Crosstalk in External Inflammatory Root Resorption},

author = {Hadagalu Revana Siddappa Rajeshwari and Anil Kishen},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85166670590&doi=10.1016%2fj.joen.2023.05.016&partnerID=40&md5=e747df72aed4f26fc292e16e60433e44},

doi = {10.1016/j.joen.2023.05.016},

issn = {00992399},

year  = {2023},

date = {2023-01-01},

journal = {Journal of Endodontics},

volume = {49},

number = {9},

pages = {1145 – 1153.e3},

publisher = {Elsevier Inc.},

abstract = {Introduction: This study aimed to understand the influence of periodontal fibroblasts (PDLFs) on clastic differentiation of macrophages (Mφ) in different resorptive environments. Methods: PDLF-Mφ direct coculture (juxtacrine) was seeded on dentin, cementum, and polystyrene with/without lipopolysaccharide, macrophage colony-stimulating factor, and receptor activator of nuclear factor kappa beta ligand for 7 and 14 days and stained for tartrate-resistant acid phosphatase (TRAP) activity. PDLF-Mφ cocultured on polystyrene were immunostained for CD80, CD206, NFATc1, STAT6, and periostin, and cell culture supernatants were assessed for cytokines on days 2 and 7. Mφ grown in conditioned media of PDLFs (paracrine) and Mφ monoculture were used as controls. Data was analyzed using Student t test and one-way analysis of variance with the Tukey multiple comparisons test (P < .05). Results: PDLF-Mφ coculture showed a higher number of TRAP-positive multinucleated cells than Mφ monoculture on dentin and polystyrene. No TRAP-positive multinucleated cells were observed in paracrine and cementum. The expression of CD80 and CD206 in PDLF-Mφ was similar at day 2, whereas CD206 was greater than CD80 at day 7. The expression of STAT6 was greater than NFATc1 at both days 2 and 7 (P < .05). Periostin expression in the presence of the lipopolysaccharide, macrophage colony-stimulating factor, and receptor activator of nuclear factor kappa beta ligand combination was down-regulated in PDLF monoculture, whereas it was up-regulated in PDLF-Mφ coculture. The cytokine profile of PDLF-Mφ on day 2 was predominated by interleukin (IL)-1β, tumor necrosis factor alpha, and MMP9 and MMP2 on day 7. IL-6 and IL-8 showed steady expression at both days 2 and 7. Conclusions: The study highlights the juxtacrine effect of PDLFs on the clastic differentiation of Mφ with a difference in clastic activity between dentin and cementum. The study also emphasizes the temporal effect of tumor necrosis factor alpha, MMP2, MMP9, and IL-1β on intercellular crosstalk in resorptive environments. © 2023 American Association of Endodontists},

note = {Cited by: 6},

keywords = {},

pubstate = {published},

tppubtype = {article}

}