Kishen contributed to the findings that the immunomodulatory properties of engineered nanoparticles resulted in polarization of macrophages to drive towards a reparative or healing phenotype. This concept is to achieve self-limiting regulated host-tissue healing as a strategy to eradicate biofilm.
Reference: Hussein H, Kishen A. Proteomic profiling reveals engineered chitosan nanoparticles mediated cellular crosstalk and immunomodulation for therapeutic application in apical periodontitis. Bioact Mater. 2021 Oct 9;11:77-89. doi: 10.1016/j.bioactmat.2021.09.032.