Welcome To The Kishen Lab

Tooth is a unique structure developed by the interaction of complex cellular events from the oral epithelium, neural ectoderm and mesoderm. The tooth / supporting structures in the mouth are biologically adapted to perform mechanical functions, while being surrounded by numerous opportunistic microbes. These tissues are protected by different levels of sophisticated immune responses against physical, chemical and most importantly microbial threats in the mouth. The immune response also regulates the characteristics of tissue regeneration and repair after therapeutic interventions. Treatment of infected dental tissues using a biomaterial-centric approach has been there for ages. However, the question is – Is the current drill and fill approach, the appropriate strategy to maintain health and functional integrity of this extremely convoluted, biologically adapted organ. Can the body’s ability to function and/or heal be utilized via well integrated biologically-based strategies for treating infected tissues?

Kishen Lab, is led by a clinician scientist who has educational background and research experience in both clinical sciences and biomedical engineering. For the past two decades, Kishen lab has been involved in engineering multifaceted biologically-based approaches for the treatment of bacterial biofilm-mediated infections.

What Do We Do?

Whats New?

Kishen collaborated to assess the effectiveness of a varnish for (a) to inhibit plaque formation and (b) as a possible replacement of fluoride varnish in orthodontic patients

This double blinded randomised controlled trial showed that the varnish (from natural source) developed in Kishen lab was as effective...
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Kishen lab collaborated to treat maxillary anterior teeth with extensive root resorption using light-activated engineered nanoparticles

In this case report, Nandini Suresh and colleagues treated a 17-year-old boy with extensive inflammatory root resorption (IRR) of maxillary...
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Kishen Lab deciphers proteomics underlying engineered chitosan nanoparticle guided immune modulation

Kishen contributed to the findings that the immunomodulatory properties of engineered nanoparticles resulted in polarization of macrophages to drive towards...
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Kishen Lab invents new multicellular organoid for regenerative research

Two-dimensional (2D) single layer of cells, cultured on flat plates are considered gold standard for cell assays. It does not...
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