“Integrating science with clinical practice”

Tooth is a unique structure developed by the interaction of complex cellular events from the oral epithelium, neural ectoderm and mesoderm. The tooth / supporting structures in the mouth are biologically adapted to perform mechanical functions, while being surrounded by numerous opportunistic microbes. These tissues are protected by different levels of sophisticated immune responses against physical, chemical and most importantly microbial threats in the mouth. The immune response also regulates the characteristics of tissue regeneration and repair after therapeutic interventions. Treatment of infected dental tissues using a biomaterial-centric approach has been there for ages. However, the question is – Is the current drill and fill approach, the appropriate strategy to maintain health and functional integrity of this extremely convoluted, biologically adapted organ. Can the body’s ability to function and/or heal be utilized via well integrated biologically-based strategies for treating infected tissues?

Kishen Lab, is led by a clinician scientist who has educational background and research experience in both clinical sciences and biomedical engineering. For the past two decades, Kishen lab has been involved in engineering multifaceted biologically-based approaches for the treatment of bacterial biofilm-mediated infections.

Click here to know more about Anil Kishen. 

OUR MAJOR RESEARCH FOCUS

LATEST RESEARCH

Clinical and Preclinical Postgraduate Training in Endodontic Education: A Transnational Exploratory Survey

Nagendrababu, V., Gopinath, V.K., Nassar, M., … Abbott, P.V., Duncan, H.F. International Dental Journal, 2025, 75(4), 100861 Introduction and aims: Endodontic postgraduate programmes should offer students …

Read More →
Investigation of the effect of addition/replacement of bioactive glass to hydraulic calcium silicate cement
Koutroulis, A., Menon, N., Kapralos, V., … Kishen, A., Sunde, P.T. Dental Materials, 2025, 41(9), pp. 1067–1079 Objectives: Assess the effect of addition or replacement of ...
Read More →
Dysfunctional crosstalk between macrophages and fibroblasts under LPS-infected and hyperglycemic environment in diabetic wounds
Sharma, S., Kishen, A.Scientific Reports, 2025, 15(1), 17233 Diabetic wounds, especially diabetic foot ulcers, present a major clinical challenge due to delayed healing and prolonged ...
Read More →

LATEST HAPPENINGS & MEDIA COVERAGE

Engage and Inform Through Impactful Presentations: My Transformative Journey

By Anil Kishen, B.D.S., M.D.S., Ph.D. Like many of you, I have had the opportunity to attend educational and scientific talks that, despite their importance, sometimes fall short of effectively engaging and informing the audience. I still vividly remember my first oral presentation on the biomechanics of endodontics at a national conference in India. After my presentation, I asked my close friends for feedback. They said, “You did well, but we didn’t understand anything.” Reflecting on that incident, I see several red flags. Presenting at a national conference in front

Read More »

From the lab to the barn: how dentistry research is being applied beyond the mouth

By Rachel Boutet Professor Anil Kishen knew nanoparticles had potential applications well beyond dentistry, but recently, he had the opportunity to see its impact on an injured horse. “We’re familiar with using nanoparticles for different purposes outside of the mouth for wound healing,” says Kishen, who is also associate dean, graduate education. “We use tunable bioactive nanoparticles for specific treatments that kill the bacteria causing infection, help modify the wound surface to allow for cellular healing, and assist in the migration of new cells to allow for wound healing. We

Read More »

Catching Up With Canada Research Chair Tier 1 Professor Anil Kishen

By Elisabeth LisicanThe future of endodontics might be nano — but the benefits could be larger than life. As announced in the August Communiqué, AAE member; Journal of Endodontics Associate Editor; and University of Toronto Faculty of Dentistry Associate Dean, Graduate Education, and Professor Anil Kishen has received Canada Research Chair Tier 1 designation and funding for his work in oral health nanomedicine. Combining his background in clinical sciences (dentistry and endodontics) and biomedical engineering, Professor Kishen has led the Kishen Lab for the past two decades. The Kishen Lab has been working

Read More »

Interview: “Nanoparticle irrigation: more than canal disinfection.” Dr Anil Kishen

This month, Dental Tribune South Asia features an exclusive interview with Dr. Anil Kishen, a globally renowned endodontist and professor with expertise in endodontic microbiology, root canal disinfection, biomechanics, and tissue engineering. Based in Toronto, Canada, Dr. Kishen is a prolific researcher and author who focuses on innovative, minimally invasive solutions to improve endodontic outcomes. Dr. Anil Kishen, can you share your journey in Endodontics and what motivated you to specialize in this field? What key moments shaped your career? As a dentist, I often encounter patients who are hesitant

Read More »

These four U of T Dentistry graduates set their sights on research and teaching

Clockwise from top left: Hebatullah Hussein, Alice (Fang-Chi) Li, Justin Bubola and Nashat Cassim. Published: November 15, 2021 By Diane Peters For some students, graduate school is a means to jump start their careers. But others plan to stay in academia to do research, teach and push their specialty forward. Justin Bubola, a graduate of the University of Toronto’s master’s program in oral pathology and oral medicine, falls into the latter category.  “I reached my goal,” says Bubola, who recently joined the Faculty of Dentistry as a part-time assistant professor, teaching stream.

Read More »

Anil Kishen, globally renowned endodontist, appointed dean of U of T’s Faculty of Dentistry

Published: April 16, 2025 By Rahul Kalvapalle Anil Kishen, a world-renowned innovator in the field of endodontics, has been appointed dean of the University of Toronto’s Faculty of Dentistry. Currently an associate scientist in the department of dentistry at Mount Sinai Hospital and the U of T Faculty of Dentistry’s associate dean of graduate education, Professor Kishen is an expert in oral microbiology and immunology whose research explores developments in bioactive nanobiomaterials and phototherapeutics to fight oral infections and improve patient outcomes.  He will assume his new role on July 1, 2025

Read More »

OUR SUPPORTING FUNDING AGENCIES

TESTIMONIALS

Scroll to Top