@article{Azarpazhooh2025401,

title = {Development of a Core Outcome Set in Endodontics (COS-ENDO): Part 1 – General Methods for Developing COS-ENDO for Studies of Nonsurgical Root Canal Treatment, Retreatment, Surgical Endodontics, Vital Pulp Therapy, Apexification, and Regenerative Endodontics in Permanent Teeth},

author = {Amir Azarpazhooh and Maryam Zanjir and Elaine Cardoso and Nicola L. Harman and Ava Khansari and Hamid Jafarzadeh and Gevik Malkhassian and Mike Sabeti and Anita Aminoshariae and Anil Kishen and Joanna E. M. Sale and Prakesh S. Shah},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105003410722&doi=10.1016%2fj.joen.2025.01.008&partnerID=40&md5=0252a383d79e2a869dff145969b1b0e4},

doi = {10.1016/j.joen.2025.01.008},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

volume = {51},

number = {4},

pages = {401 – 411},

publisher = {Elsevier Inc.},

abstract = {Introduction: Methodological heterogeneity and reporting bias complicate interpreting endodontic outcomes. Supported by the American Association of Endodontists and its Foundation, this study developed the Core Outcome Set in Endodontics (COS-ENDO) to standardize reporting for studies of nonsurgical root canal treatment/retreatment, surgical endodontics, vital pulp therapy, apexification, and regenerative endodontics. This article, the first in a 5-part series, outlines the methods for developing COS-ENDO, with detailed findings for each treatment presented in subsequent parts. Methods: Outcomes were identified through scoping reviews, a qualitative study with patients, and a web-based survey of American Association of Endodontists practicing members. In a 2-round Delphi survey, clinicians, patients, and researchers rated outcomes on a 9-point scale. Ratings were assessed against consensus criteria, and a virtual meeting finalized COS-ENDO. Results: Of the 97 invited participants to round 1, 77 (79%) registered and 73 (95%) completed the survey, including 24 academicians/researchers, 26 clinicians, and 23 patients (or their caregivers/parents). They rated 64 outcomes, totaling 182 occurrences across treatments: 39 for nonsurgical root canal treatment/retreatment, 46 for surgical endodontics, 46 for vital pulp therapy, and 51 for apexification/regenerative endodontics. The outcomes that achieved consensus for inclusion and those lacking consensus (either for inclusion or exclusion) advanced to round 2 for rerating by 70 participants. During the final consensus meeting, 16 participants discussed the outcomes and finalized the COS-ENDO. Conclusion: COS-ENDO is an important step toward standardizing outcome reporting in endodontics. Its implementation will ensure consistent reporting, enhancing research utility and evidence synthesis. Further efforts are needed to establish optimal measurement methods. © 2025 The Authors},

note = {Cited by: 4},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae2025103,

title = {Insights into the February 2025 Issue of the JOE},

author = {Anita Aminoshariae and Amir Azarpazhooh and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Ronald Ordinola-Zapata and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85216608626&doi=10.1016%2fj.joen.2025.01.017&partnerID=40&md5=e84c78d0a002514d4b956ee3d07eec95},

doi = {10.1016/j.joen.2025.01.017},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

volume = {51},

number = {2},

pages = {103 – 105},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lin2025674,

title = {Unraveling the Etiology and Pathogenesis of Multiple Cervical Root Resorption – A Scoping Review},

author = {Yuhong Lin and Vivek Thumbigere-Math and Anil Kishen and Jianing He},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105000038037&doi=10.1016%2fj.joen.2025.02.012&partnerID=40&md5=54d1864cfe18c839f628382aaa41c252},

doi = {10.1016/j.joen.2025.02.012},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

volume = {51},

number = {6},

pages = {674 – 686},

publisher = {Elsevier Inc.},

abstract = {Introduction: Multiple Cervical Root Resorption (MCRR) is a rare condition characterized by the progressive destruction of the cervical region of multiple tooth roots, leading to significant tooth loss. The etiology and pathogenesis of MCRR remain poorly understood. Existing knowledge is largely derived from case reports/series. A comprehensive review of literature is crucial to identify potential systemic and dental factors that contribute to the development and progression of MCRR. Methods: A scoping review was conducted following PRISMA guidelines. Five major health science databases were systematically searched to capture all reported cases of MCRR published to date. Potential etiologic factors were identified and categorized based on their association with MCRRs. Results: A total of 65 reports documenting 101 patients and involving 921 teeth were included in the analysis. The review identified several potential etiologic factors, including skeletal disorders, autoimmune diseases, viral infections, genetic diseases, specific genetic mutations, liver dysfunctions, the use of antiresorptive medications, and endocrine disturbances. Each of these factors may influence osteoclast/odontoclast functioning, implicating them in the pathogenesis of MCRR. Conclusions: Systemic diseases and medications that alter bone remodeling process or osteoclast/odontoclast function play a significant role in the development of a large proportion of MCRR cases. Given the complex and multifactorial nature of this condition, an interdisciplinary approach involving general dentists, specialists, and physicians is essential. Early detection, prevention, and personalized management of MCRR are critical in minimizing the risk of extensive tooth loss and improving patient outcomes. © 2025 American Association of Endodontists},

note = {Cited by: 1},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Zanjir2025457,

title = {Development of a Core Outcome Set in Endodontics (COS-ENDO): Part 5 – COS-ENDO for Studies of Apexification and Regenerative Endodontics in Permanent Teeth},

author = {Maryam Zanjir and Elaine Cardoso and Nicola L. Harman and Ava Khansari and Hamid Jafarzadeh and Gevik Malkhassian and Mike Sabeti and Anita Aminoshariae and Anil Kishen and Joanna E. M. Sale and Prakesh S. Shah and Amir Azarpazhooh},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105003500250&doi=10.1016%2fj.joen.2025.01.012&partnerID=40&md5=30d4835f988a176efcd0eed9173d92d2},

doi = {10.1016/j.joen.2025.01.012},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

volume = {51},

number = {4},

pages = {457 – 472},

publisher = {Elsevier Inc.},

abstract = {Introduction: Methodological heterogeneity and reporting bias complicate interpreting endodontic outcomes. Supported by the American Association of Endodontists and its Foundation, this study developed the Core Outcome Set in Endodontics (COS-ENDO) to standardize reporting for studies of Nonsurgical Root Canal Treatment/Retreatment, Surgical Endodontics, Vital Pulp Therapy, Apexification, and Regenerative Endodontics. This article, the last in a 5-part series, focuses on COS-ENDO for Apexification and Regenerative Endodontics, while other parts address the remaining treatments. Methods: Outcomes were identified through scoping reviews and a web-based survey of American Association of Endodontists practicing members. In a 2-round Delphi survey, clinicians, patients, and researchers rated outcomes on a 9-point scale. Ratings were assessed against consensus criteria, and a virtual meeting finalized COS-ENDO. Results: Of the 97 invited participants to Round 1, 77 registered, and 73 (24 Academicians/Researchers, 26 Clinicians, and 23 Patients or their parents/caregivers) assessed 51 outcomes, with 18 excluded. The remaining outcomes—7 achieving consensus for inclusion and 26 lacking consensus—advanced to Round 2 for re-rating by 70 participants. This resulted in 14 outcome achieving consensus for inclusion, and 19 lacking consensus. In the final meeting, 16 participants finalized the COS-ENDO for Apexification and Regenerative Endodontics, including Tooth survival, Pain, Signs of infection, Radiographic evidence of periradicular healing, Continued root development, Success, Functional tooth, Need for further intervention, and Adverse events/Complications. Conclusion: COS-ENDO is an important step in standardizing outcome reporting in endodontics, ensuring consistent reporting and enhancing research utility. Further efforts are needed to establish optimal measurement methods. © 2025 The Authors},

note = {Cited by: 4},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae20251,

title = {Insights Into the January 2025 Issue of the Journal of Endodontics},

author = {Anita Aminoshariae and Amir Azarpazhooh and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Ronald Ordinola-Zapata and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85212822422&doi=10.1016%2fj.joen.2024.12.005&partnerID=40&md5=b61c2b3e78429658b5e61d09851015ef},

doi = {10.1016/j.joen.2024.12.005},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

volume = {51},

number = {1},

pages = {1 – 3},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Sharma2025,

title = {Dysfunctional crosstalk between macrophages and fibroblasts under LPS-infected and hyperglycemic environment in diabetic wounds},

author = {Shivam Sharma and Anil Kishen},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105005425971&doi=10.1038%2fs41598-025-00673-4&partnerID=40&md5=aea4083df255271aba9c650e436064db},

doi = {10.1038/s41598-025-00673-4},

issn = {20452322},

year  = {2025},

date = {2025-01-01},

journal = {Scientific Reports},

volume = {15},

number = {1},

publisher = {Nature Research},

abstract = {Diabetic wounds, especially diabetic foot ulcers, present a major clinical challenge due to delayed healing and prolonged inflammation. Macrophage-fibroblast interactions are essential for wound repair, yet this crosstalk is disrupted in diabetic wounds due to hyperglycemia and bacterial infection. This study investigates the dysfunctional communication between macrophages and fibroblasts, focusing on autocrine, paracrine, and juxtacrine signaling in simulated diabetic environments. Using monoculture and co-culture models of THP-1-derived macrophages and primary human dermal fibroblasts, we simulated conditions of normal glucose, LPS-induced infection, high glucose (with AGEs), and combined high glucose (with AGEs) and LPS. Macrophages in hyperglycemic and LPS-infected environments exhibited a pro-inflammatory M1 phenotype with elevated expression of CD80, and STAT1 and increased production of IL-1β, TNF-α, and MMP9. Fibroblast migration was significantly impaired under high glucose conditions, particularly in paracrine model. Secretome profiling showed heightened pro-inflammatory cytokines and proteases, with reduced anti-inflammatory markers (IL-10 and VEGF-A) under hyperglycemic conditions. Paracrine signaling exacerbated the inflammatory response, while juxtacrine signaling showed more moderate effects, conducive to healing. These findings highlight the pathological macrophage-fibroblast crosstalk in diabetic wounds, particularly under hyperglycemic and LPS-infected conditions, offering insights for potential immunomodulatory therapies aimed at restoring effective signaling and improving wound healing outcomes. © The Author(s) 2025.},

note = {Cited by: 1},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rosa2025248,

title = {Guidance for evaluating biomaterials’ properties and biological potential for dental pulp tissue engineering and regeneration research},

author = {Vinicius Rosa and Bruno Neves Cavalcanti and Jacques E. Nör and Arzu Tezvergil-Mutluay and Nikolaos Silikas and Marco C. Bottino and Anil Kishen and Diana Gabriela Soares and Cristiane M. Franca and Paul Roy Cooper and Henry F. Duncan and Jack L. Ferracane and David C. Watts},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85212323447&doi=10.1016%2fj.dental.2024.12.003&partnerID=40&md5=230be341904af879bde183254bb26460},

doi = {10.1016/j.dental.2024.12.003},

issn = {01095641},

year  = {2025},

date = {2025-01-01},

journal = {Dental Materials},

volume = {41},

number = {3},

pages = {248 – 264},

publisher = {Elsevier Inc.},

abstract = {Background: Dental pulp regeneration is a complex and advancing field that requires biomaterials capable of supporting the pulp's diverse functions, including immune defense, sensory perception, vascularization, and reparative dentinogenesis. Regeneration involves orchestrating the formation of soft connective tissues, neurons, blood vessels, and mineralized structures, necessitating materials with tailored biological and mechanical properties. Numerous biomaterials have entered clinical practice, while others are being developed for tissue engineering applications. The composition and a broad range of material properties, such as surface characteristics, degradation rate, and mechanical strength, significantly influence cellular behavior and tissue outcomes. This underscores the importance of employing robust evaluation methods and ensuring precise and comprehensive reporting of findings to advance research and clinical translation. Aims: This article aims to present the biological foundations of dental pulp tissue engineering alongside potential testing methodologies and their advantages and limitations. It provides guidance for developing research protocols to evaluate the properties of biomaterials and their influences on cell and tissue behavior, supporting progress toward effective dental pulp regeneration strategies © 2024 The Authors},

note = {Cited by: 2; All Open Access, Hybrid Gold Open Access},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae2025397,

title = {Insights into the April 2025 Issue of the JOE},

author = {Anita Aminoshariae and Amir Azarpazhooh and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Ronald Ordinola-Zapata and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105003373997&doi=10.1016%2fj.joen.2025.03.006&partnerID=40&md5=89be79d6c40436959d2d7c0005888ce1},

doi = {10.1016/j.joen.2025.03.006},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

volume = {51},

number = {4},

pages = {397 – 398},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Nagendrababu2025,

title = {Clinical and Preclinical Postgraduate Training in Endodontic Education: A Transnational Exploratory Survey},

author = {Venkateshbabu Nagendrababu and Vellore Kannan Gopinath and Mohannad Nassar and Naresh Shetty and Anil Kishen and Paul V. Abbott and Henry F. Duncan},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105007912646&doi=10.1016%2fj.identj.2025.100861&partnerID=40&md5=ee36e81a31a4b439f4b5c83e4c9019a5},

doi = {10.1016/j.identj.2025.100861},

issn = {00206539},

year  = {2025},

date = {2025-01-01},

journal = {International Dental Journal},

volume = {75},

number = {4},

publisher = {Elsevier Inc.},

abstract = {Introduction and aims: Endodontic postgraduate programmes should offer students a wide range of experiences and training in all facets of the specialisation. This study aimed to assess the current postgraduate education practices in endodontics across dental schools worldwide. Methods: The current survey consisted of an online questionnaire that had been validated and piloted. It comprised 68 questions in three sections: general information about the programme, preclinical education, and clinical education. The survey included faculty members who teach postgraduate endodontics from one dental school in each participating country. The data was presented using simple descriptive statistics. Results: In total, 33 faculty members, with a response rate of 85%, from different countries completed the survey. The majority of dental schools that participated in the survey offer a 3-year postgraduate programme. The postgraduate students develop abilities in various instrumentation techniques, irrigation devices, sealers/cements, root canal filling techniques, surgery, and microscope use. Most of the schools conduct a final-year exit examination. Conclusions: Postgraduate education differs globally in its preclinical and clinical training. The survey offers initial insights into postgraduate endodontic education and can help establish mutual educational standards and key focus areas. Clinical relevance: The curricula for preclinical and clinical education in postgraduate endodontics programmes vary globally. © 2025 The Authors},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{deCarvalho2025,

title = {Dynamic photoelastic analysis of stress distribution in simulated canals using different heat-treated flat-side rotary instruments},

author = {Kleber Kildare Teodoro Carvalho and Paulo Takeji Moriya and Anil Kishen and Jorge N. R. Martins and Emmanuel João Nogueira Leal Silva and Murilo P. Alcalde and Francisco Manuel Braz Fernandes and Erick Miranda Souza and Marco Aurélio Versiani},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85218104198&doi=10.1007%2fs00784-025-06193-9&partnerID=40&md5=f69fcce6b8cc207dbce058ed05035595},

doi = {10.1007/s00784-025-06193-9},

issn = {14326981},

year  = {2025},

date = {2025-01-01},

journal = {Clinical Oral Investigations},

volume = {29},

number = {2},

publisher = {Springer Science and Business Media Deutschland GmbH},

abstract = {Objectives: This study aimed to compare the stress produced by three heat-treated flat-side prototype rotary instruments and a non-flat side instrument on the internal walls of simulated canals with three different curvature degrees using the photoelastic technique. Materials and methods: Thirty-six resin blocks with simulated canals, comprising three curvature types (45°, 60°, and double curvature), were used in the study, with 12 blocks allocated to each curvature type. These blocks were further divided into four experimental groups (n = 9 per group) based on the heat treatment of the instruments: gold, silver, blue, and a control group with non-flat-side gold instruments. The blocks were analyzed using a circular polariscope setup, with real-time birefringence patterns captured by a digital camera. Stress on canal walls was evaluated using a semi-quantitative scale. Supplementary tests (stereomicroscope, SEM, energy-dispersive X-ray spectroscopy, and DSC) were performed to interpret the results further. Data were analyzed using the Kruskal-Wallis test (α = 5%). Results: Inter- and intra-observer agreements were 0.91 and 1, respectively. All instruments exhibited high stress patterns on canal walls. The highest stress was observed in the 45° and 60° blocks (middle third) and the double curvature blocks (apical third). The flat-side gold instrument recorded the highest stress in the coronal third, and the flat-side blue in the apical third (p < 0.05). All instruments displayed some degree of distortion after use. Conclusions: Instrument type and canal curvature significantly influenced stress distribution across root canal thirds. All flat-side instruments exhibited high stress patterns, warranting caution in curved canals due to potential distortion and performance impact. Clinical relevance: This study recommended caution when using newly designed flat-side instruments in curved canals due to potential stress on canal walls and greater distortion, which may affect performance and durability. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.},

note = {Cited by: 1},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{deOliveiraSales-Junior2025,

title = {Systemic administration of polyphenols from dealcoholized red wine reduces inflammation and bone resorption in established apical periodontitis in male rats},

author = {Romulo Oliveira Sales-Junior and Bharbara Moura Pereira and Rafaela Ricci and Nathália Evelyn Silva Machado and Julissa Denisse Arguello Alvarado and Ana Beatriz Carreto and Edilson Ervolino and Anil Kishen and Luciano Tavares Ângelo Cintra and João Eduardo Gomes-Filho},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85218276257&doi=10.1016%2fj.archoralbio.2025.106206&partnerID=40&md5=2ed8e6efaca530983656b09aa3fca7e6},

doi = {10.1016/j.archoralbio.2025.106206},

issn = {00039969},

year  = {2025},

date = {2025-01-01},

journal = {Archives of Oral Biology},

volume = {173},

publisher = {Elsevier Ltd},

abstract = {Objective: To analyze the effect of supplementation with dealcoholized red wine on the severity of apical periodontitis after it had been established. Design: Thirty-two male Wistar rats were arranged into four groups: water as control, dealcoholized red wine, red wine, and alcohol. Apical periodontitis was induced by pulp exposure for 30 days when supplementation started and continued daily for 30 days. After the supplementation period, the rats were euthanized, and maxillae and jaws were removed to evaluate the inflammatory response and the bone resorption through microtomographic, histological and immunohistochemical analysis. Statistical tests were applied at 5 % significance. Results: The dealcoholized red wine group demonstrated a significant reduction in bone resorption volume and increase in bone volume fraction and trabecular parameters (p < 0.05). The dealcoholized red wine and red wine groups exhibited mild inflammation compared to the control and alcohol groups that showed moderate and severe inflammation respectively (p < 0.05). The immunoreaction was significantly lower in the dealcoholized red wine group than in the control and alcohol groups for the TNF-α, IL-1β and TRAP cells (p < 0.05). Furthermore, OPG in dealcoholized red wine was similar to red wine and control but higher than in the alcohol group (p < 0.05). Conclusion: Supplementation with dealcoholized red wine in rats decreased inflammation and bone loss in established apical periodontitis. This study highlights the potential of systemic administration of polyphenols from red wine in decreasing inflammation and bone resorption of established apical periodontitis in rats. © 2025 Elsevier Ltd},

note = {Cited by: 1},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae2025825,

title = {Insights into the July 2025 Issue of the JOE},

author = {Anita Aminoshariae and Amir Azarpazhooh and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Ronald Ordinola-Zapata and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105009439791&doi=10.1016%2fj.joen.2025.06.007&partnerID=40&md5=f58af2b56fbf8ef3c06b41dc5bec1f3b},

doi = {10.1016/j.joen.2025.06.007},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

volume = {51},

number = {7},

pages = {825 – 827},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae2025535,

title = {Insights into the May 2025 Issue of the JOE},

author = {Anita Aminoshariae and Amir Azarpazhooh and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Ronald Ordinola-Zapata and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105005427088&doi=10.1016%2fj.joen.2025.05.001&partnerID=40&md5=1c6478899f7ab97089791675858ded22},

doi = {10.1016/j.joen.2025.05.001},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

volume = {51},

number = {5},

pages = {535 – 537},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae2025255,

title = {Insights into the March 2025 Issue of the JOE},

author = {Anita Aminoshariae and Amir Azarpazhooh and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Ronald Ordinola-Zapata and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105000044746&doi=10.1016%2fj.joen.2025.02.005&partnerID=40&md5=5e7635ade7f8303baf2bd55d6725c1b8},

doi = {10.1016/j.joen.2025.02.005},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

volume = {51},

number = {3},

pages = {255 – 257},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Gopalasamy2025,

title = {Impact of Multispecies Biofilm on the Chemical and Mechanical Characteristics of Radicular Dentin from Patients With and Without Diabetes: An In Vitro Study},

author = {Kirtana Gopalasamy and Sridevi Krishnamoorthy and Jayalakshmi Somasundaram and Tiju Thomas and Angambakkam Rajasekaran PradeepKumar and Anil Kishen},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105009095782&doi=10.1016%2fj.joen.2025.05.028&partnerID=40&md5=47dc7cffab42d36492bc0696553c86e0},

doi = {10.1016/j.joen.2025.05.028},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

publisher = {Elsevier Inc.},

abstract = {Introduction: This in vitro study examined the effect of a multispecies biofilm on the chemical characteristics and mechanical properties of root dentin from patients with or without type 2 diabetes mellitus (DM). Methods: Intact mandibular molars were obtained from diabetic and nondiabetic donors. Rectangular root dentin beams were prepared and categorized based on age (40–60 and 61–80 years), presence/absence of DM, and the site of dentin beam extraction (mesiodistal or buccolingual). Pentosidine, collagen cross-linking ratio, and mineral-to-collagen ratio were determined by Fourier transform infrared spectroscopy and fatigue resistance was evaluated by the four-point flexure to failure test with or without exposure to a multispecies biofilm for 21 days. Results: DM and biofilm exposure significantly increased pentosidine, mineral-to-collagen ratio, and collagen cross-linking ratio in root dentin from both age groups (P < .05). Control root dentin from the 61–80 years group had significantly lower fatigue resistance than root dentin from the 40–60 years group (P < .05). DM reduced the fatigue resistance of root dentin but not significantly (P > .05). After biofilm exposure, root dentin with DM had significantly lower fatigue resistance than root dentin without DM (P < .05). Biofilm exposure significantly reduced the fatigue resistance of root dentin with or without DM when compared with the controls only in the 40–60 years group (P < .05). Conclusions: Aging decreased the fatigue resistance of root dentin. DM and biofilm exposure increased pentosidine, mineral-to-collagen ratio, and collagen cross-linking in root dentin across both age groups. Biofilm exposure further reduced the fatigue resistance of root dentin with DM compared to root dentin without DM. © 2025 American Association of Endodontists},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Zanjir2025427,

title = {Development of a Core Outcome Set in Endodontics (COS-ENDO): Part 3 – COS-ENDO for Studies of Surgical Endodontics in Permanent Teeth},

author = {Maryam Zanjir and Elaine Cardoso and Nicola L. Harman and Ava Khansari and Hamid Jafarzadeh and Gevik Malkhassian and Mike Sabeti and Anita Aminoshariae and Anil Kishen and Joanna E. M. Sale and Prakesh S. Shah and Amir Azarpazhooh},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105003393754&doi=10.1016%2fj.joen.2025.01.011&partnerID=40&md5=a81f592337d246585e5e1b3343cff2ed},

doi = {10.1016/j.joen.2025.01.011},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

volume = {51},

number = {4},

pages = {427 – 441},

publisher = {Elsevier Inc.},

abstract = {Introduction: Methodological heterogeneity and reporting bias complicate interpreting endodontic outcomes. Supported by the American Association of Endodontists and its Foundation, this study developed the Core Outcome Set in Endodontics (COS-ENDO) to standardize reporting for studies of nonsurgical root canal treatment/retreatment, surgical endodontics, vital pulp therapy, apexification, and regenerative endodontics. This article, part 3 of a 5-part series, focuses on COS-ENDO for surgical endodontics, while other parts address the remaining treatments. Methods: Outcomes were identified through a scoping review, a qualitative study with patients, and a web-based survey of American Association of Endodontists practicing members. In a 2-round Delphi survey, clinicians, patients, and researchers rated outcomes on a 9-point scale. Ratings were assessed against consensus criteria, and a virtual meeting finalized COS-ENDO. Results: Of the 97 invited participants to round 1, 77 registered, and 73 (24 academicians/researchers, 26 clinicians, and 23 patients or their parents/caregivers) assessed 46 outcomes, with 17 excluded. The remaining outcomes—7 achieving consensus for inclusion and 22 lacking consensus—advanced to round 2 for rerating by 70 participants. This resulted in 1 outcome achieving consensus for exclusion, 10 for inclusion, and 18 lacking consensus. In the final meeting, 16 participants finalized the COS-ENDO for surgical endodontics, including Tooth survival, Pain, Signs of infection, Radiographic evidence of periradicular healing, Success, Functional tooth, Need for further intervention, and Adverse events/Complications. Conclusions: COS-ENDO is an important step in standardizing outcome reporting in endodontics, ensuring consistent reporting and enhancing research utility. Further efforts are needed to establish optimal measurement methods. © 2025 The Authors},

note = {Cited by: 4},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Nosrat2025,

title = {Biomechanical Characterization of Immature Roots Following Regenerative Endodontic Treatment and MTA Apexification: A Clinical Study},

author = {Ali Nosrat and Alireza Kolahdouzan and Rajeshwari Hadagalu Revana Siddappa and Changjun Cheng and Fang-Chi Li and Meisam Moradi and Amir Hossein Khatibi and Davoud Jamshidi and Azin Parsa and Jeffery B. Price and Anibal Diogenes and Yu Zou and Anil Kishen},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105010946945&doi=10.1016%2fj.joen.2025.06.018&partnerID=40&md5=dafe96cec694bf90d6e5ca065630cf7e},

doi = {10.1016/j.joen.2025.06.018},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

publisher = {Elsevier Inc.},

abstract = {Introduction: This clinical investigation aims to determine and compare the volume, hardness, and elastic modulus of immature roots following regenerative endodontic treatment (RET) and mineral trioxide aggregate (MTA) apexification. Methods: A total of six volunteers aged between 9 and 14 years participated in the study, each providing a pair of mandibular or maxillary premolars with normal pulp and periapex planned for extraction due to orthodontic reasons. After full pulpectomy, each pair received either an MTA obturation or RET using blood clot as scaffold, followed by permanent restoration. Teeth were extracted ∼6.5 months later. Micro–computed tomographic images of teeth were taken for volumetric analyses and roots were subjected to nanoindentation physical testing. Results: Root volumes ranged from 168 mm3–236 mm3 (202.5 ± 31.07) in the MTA group and 178 mm3–251 mm3 (223 ± 28.09) in the RET group (P < .05). The median values of hardness in all regions (apical and middle) and all sites (periphery to canal lumen) ranged from 0.56–1.04 giga pascal (GPa) in the MTA group and 0.32–0.65 GPa in the RET group (P < .05). The median values of elastic modulus in all regions (apical and middle) and all sites (periphery to canal lumen) ranged from 10.4–22.9 GPa in the MTA group and 4.8–12.1 GPa in the RET groups (P < .05). Except the hardness in apical third in the MTA group, the values of hardness and elastic modulus increased from periphery towards lumen in all other regions in both groups (P < .05). Conclusions: After a period of 6.5 months RET resulted in increased root volumes, with the root structure indicative of newly formed hard tissue, which exhibited lower hardness and elastic modulus compared to those treated with MTA apexification. © 2025 The Authors},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Meyerson202578,

title = {Photomechanical Investigation on the Impact of Endodontic Cavity Design on the Biomechanical Response in Mandibular Posterior Teeth},

author = {Danielle Meyerson and Fang-Chi Li and Anil Kishen},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85210086565&doi=10.1016%2fj.joen.2024.11.002&partnerID=40&md5=5c26c00c45a56fff52b29a875143ba82},

doi = {10.1016/j.joen.2024.11.002},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

volume = {51},

number = {1},

pages = {78 – 84},

publisher = {Elsevier Inc.},

abstract = {Introduction: The traditional endodontic cavity (TEC) facilitates canal preparation, but may increase susceptibility to root fracture; conservative endodontic cavities (CEC) aim to preserve tooth structure to maintain the structural integrity of root-filled teeth. The objective of this study was to evaluate the effect of access cavity design and the degree of pulp chamber root removal on the microstrain distribution patterns under different levels of functional loading using digital moiré interferometry. Methods: Twelve extracted human teeth (n = 12) were included, comprising of mandibular premolars (n = 6) and mandibular first molars (n = 6). Specimens were subjected to physiologic levels of compressive loading ranging from 10 to 50 N for each group. Digital moiré interferometry fringe patterns were acquired three times for each pecimen: prior to endodontic cavity preparation (control group (CG)), after conservative endodontic cavity preparation (CEC), and following traditional endodontic cavity preparation (TEC). The acquired fringe patterns were used to determine the microstrain distribution at the coronal and cervical dentin. The data were analyzed qualitatively and quantitatively using one-way ANOVA and T-tests (P < .05). Results: The intact crowns of CG teeth showed significantly less microstrain, when compared to CEC and TEC with a distinct shift in coronal microstrain in both CEC and TEC groups. There were significant differences between both the coronal and cervical microstrain in the CG, CEC, and TEC groups. Conclusions: The roof of the pulp chamber contributes to a distinct biomechanical response in posterior teeth. The microstrain at the coronal and cervical level increased significantly following de-roofing of the pulp chamber in both CEC and TEC groups, with the TEC resulting in higher coronal microstrain compared to CEC group. © 2024 The Authors},

note = {Cited by: 1},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Aminoshariae2025655,

title = {Insights into the June 2025 Issue of the JOE},

author = {Anita Aminoshariae and Amir Azarpazhooh and Gerald N. Glickman and Jianing He and Sahng G. Kim and Anil Kishen and Ariadne M. Letra and Linda Levin and Ronald Ordinola-Zapata and Frank C. Setzer and Franklin R. Tay and Kenneth M. Hargreaves},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105007721849&doi=10.1016%2fj.joen.2025.05.017&partnerID=40&md5=d33df821e5037067f79c89934382cbc9},

doi = {10.1016/j.joen.2025.05.017},

issn = {00992399},

year  = {2025},

date = {2025-01-01},

journal = {Journal of Endodontics},

volume = {51},

number = {6},

pages = {655 – 657},

publisher = {Elsevier Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Alsuwaidi2025,

title = {Antibacterial and Antibiofilm Efficacy of Green Synthesised Haloxylon Capped Silver Nanoparticles Against Enterococcus faecalis},

author = {Rawda O. Alsuwaidi and Priyadharshini Sekar and Abdelaziz Elgamouz and Shashikant P. Patole and Alaa Alatta and Anil Kishen and Venkateshbabu Nagendrababu},

url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105006435721&doi=10.1111%2faej.12948&partnerID=40&md5=61149f8229b5aa4524269479c85b1017},

doi = {10.1111/aej.12948},

issn = {13291947},

year  = {2025},

date = {2025-01-01},

journal = {Australian Endodontic Journal},

publisher = {John Wiley and Sons Inc},

abstract = {This study synthesised and characterised Haloxylon-capped silver nanoparticles (Haloxylon-AgNPs) and assessed their antibacterial and antibiofilm activity against Enterococcus faecalis. The study also examined Haloxylon-AgNPs' ability to target E. faecalis biofilms in root canals. Haloxylon salicornicum extract was used to synthesise silver nanoparticles. Physiochemical characterisation of Haloxylon-AgNPs was conducted. Antimicrobial and antibiofilm activity of Haloxylon-AgNPs was studied by agar diffusion method, minimum inhibitory concentration (MIC) determination, time-kill assay, confocal laser scanning microscopy (CLSM) and qPCR for virulence gene attenuation. One hundred and twenty extracted teeth were infected with E. faecalis and treated with either Haloxylon-AgNPs, chlorhexidine, calcium hydroxide or saline. The data were analysed using a one-way ANOVA and Tukey multiple comparison test to investigate the bacterial reduction between groups (p < 0.05, significant; p < 0.001, highly significant). A significant reduction in the thickness of biofilm and expression of cylA virulence gene of Haloxylon-AgNPs treated E. faecalis was observed. No difference was observed between Haloxylon-AgNPs, chlorhexidine and calcium hydroxide in the tooth model. © 2025 Australian Society of Endodontology Inc.},

note = {Cited by: 0},

keywords = {},

pubstate = {published},

tppubtype = {article}

}